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Procaine Benzylpenicillin for Powder Injection
(01) Specification
ul
(02) Packing
100 mL per bottle.
Procaine Benzylpenicillin for Powder Injection
- Ingredients
- Each bottle contains: procaine penicillin 3 million units, benzylpenicillin sodium 1 million units.
- Description
- White or slightly yellow sterile powder.
- Pharmacologic Actions
- Penicillin is a narrow-spectrum antibiotic that acts primarily against a wide range of Gram-positive bacteria and a few Gram-negative cocci. The main sensitive bacteria include staphylococci, streptococci, Mycobacterium tuberculosis, Mycobacterium rods, Clostridium tetani, Actinobacillus, Bacillus anthracis, and Spirochetes. Insensitive to Mycobacterium, Mycoplasma, Chlamydia, Rickettsia, Nocardia, fungi and viruses.
Pharmacokinetics: after intramuscular injection of procaine penicillin, penicillin is released through local hydrolysis and absorbed slowly. Peak time is longer, blood concentration is lower, but the duration of action is longer than penicillin. It is limited to pathogens that are highly sensitive to penicillin and should not be used to treat serious infections. Procaine penicillin mixed with penicillin sodium (potassium) injection can increase the blood concentration in a short period of time, both long-acting and fast-acting effects. Large injections of procaine penicillin can cause procaine toxicity.
- Drug interactions
- The combined use of penicillin and aminoglycosides can increase the concentration of the latter in bacteria with a synergistic effect.
Macrolides, tetracyclines and aminoglycosides and other rapid-acting bacteriostatic agents have an interfering effect on the bactericidal activity of penicillin and should not be combined.
Heavy metal ions (especially copper, zinc, mercury), alcohols, acids, iodine, oxidizing agents, reducing agents, hydroxyl compounds, acidic dextrose injections or tetracycline hydrochloride injections can destroy the activity of penicillin, is contraindicated.
Amines and penicillin can form insoluble salts that alter absorption. This interaction can delay the absorption of penicillin, e.g. procaine penicillin.
Certain drug solutions (e.g., chlorpromazine hydrochloride, lincomycin hydrochloride, norepinephrine tartrate, oxytetracycline hydrochloride, tetracycline hydrochloride, vitamin B, and vitamin C) should not be mixed, as turbidity, flocculation, or precipitation may result.
- Indications
- It is mainly used for the treatment of chronic infections caused by bacteria sensitive to penicillin, such as bovine uterine pus accumulation, mastitis, bone fracture, etc. It is also used for infections caused by Actinobacillus and Leptospira.
- Usage dosage
- Intramuscular injection. Single dose, 10,000-20,000 units per kilogram of body weight for horses and cattle; 20,000-30,000 units for sheep, pigs, donkeys and calves; 30,000-40,000 units for dogs and cats. Apply once daily for 2-3 days. Add appropriate amount of sterile water to make a suspension before use.
- Adverse Reactions
- The major adverse reaction is anaphylaxis, which can occur in most domestic animals but has a low incidence. Local reactions are characterized by edema and pain at the injection site, and systemic reactions are hives and rashes. In severe cases, shock or death may result.
Gastrointestinal double infections can be induced in some animals.
- Precautions
- This product is intended only for the treatment of chronic infections caused by bacteria highly susceptible to penicillin.
It is slightly soluble in water and will rapidly become ineffective when exposed to acids, alkalis or oxidizing agents. Therefore, the injection should be prepared and used now.
Pay attention to the interactions with other drugs and contraindications of pairing, so as not to affect the efficacy.
- Withdrawal period
- Cattle, sheep and swine: 28 days; milk: 72 hours.
- Storage
- Sealed and placed in a dry place.
- Specification
- 4 million (procaine 3 million + penicillin 1 million)/ul
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